Abiraterone 500mg is a higher-strength tablet that allows the standard daily dose to be taken as fewer tablets. This Abiraterone 500mg prostate cancer guide covers how it is used and the precautions that apply.
What Is It?
Abiraterone acetate blocks CYP17, an enzyme needed to produce testosterone and related hormones throughout the body, and is used for advanced prostate cancer alongside a steroid.
How Does It Work?
By cutting off androgen production, including within the tumour itself, abiraterone slows or stops the growth of hormone-sensitive prostate cancer cells.
Who Is It Prescribed For?
Adults with metastatic castration-resistant or high-risk hormone-sensitive prostate cancer, under oncology or urology care.
Dosage and How to Take It
Typically taken as two 500mg tablets once daily to reach the standard 1,000mg dose. Must be taken on a strictly empty stomach, at least one hour before or two hours after food, alongside your prescribed steroid dose.
What If I Miss a Dose?
If a dose is missed, skip it and resume the normal schedule the next day rather than doubling up.
Common Side Effects
Swelling in the legs or ankles
High blood pressure
Fatigue
Hot flashes
Low potassium (checked by blood tests)
Serious Side Effects, Seek Help If You Notice:
Signs of liver injury: jaundice, dark urine, severe tiredness
Signs of low cortisol if steroid doses are missed: weakness, dizziness, fainting
Irregular heartbeat
Warnings and Precautions
As outlined in this Abiraterone 500mg prostate cancer guide, regular liver function tests, blood pressure checks, and potassium monitoring are required throughout treatment. Never stop the accompanying steroid suddenly without medical advice.
Drug and Food Interactions
Must be taken on an empty stomach for predictable absorption. Interacts with a range of medicines processed by the liver; give your pharmacist your complete medicine list.
Storage
Store below 30°C in the original container, away from direct sunlight and moisture. Pregnant women should avoid handling broken or crushed tablets.
Frequently Asked Questions
Is the 500mg tablet stronger per milligram than the 250mg tablet? No, it is the same medicine at a higher tablet strength, simply allowing the same total daily dose to be taken in fewer tablets.
Can I take my two tablets at different times of day? No, both tablets should be taken together at the same time, on an empty stomach, exactly as directed by your doctor.
This article is reviewed by Pharmacist Sesan Kareem, B.Pharm, MPA, MBA and is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always take medicines exactly as prescribed by your doctor. Chat with a HubPharm pharmacist on WhatsApp with any questions before starting, stopping, or changing a medicine.
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