Rectogesic is a topical ointment used to ease the pain of anal fissures without surgery for many patients. Here’s how it works and how to apply it correctly, as detailed in this Rectogesic ointment fissure guide.
What Is It?
Rectogesic contains glyceryl trinitrate (GTN), a nitrate medicine that relaxes smooth muscle. Applied rectally, it targets the anal sphincter directly rather than being swallowed.
How Does It Work?
It relaxes the internal anal sphincter muscle and improves local blood flow, reducing the muscle spasm that causes fissure pain and supporting the fissure’s natural healing.
Who Is It Prescribed For?
Adults with chronic anal fissure pain, prescribed by a doctor after examination.
Dosage and How to Take It
A measured strip of ointment, as directed by your doctor or pharmacist using the dosing applicator provided, is applied to the anal area, typically every 12 hours, for up to 8 weeks unless advised otherwise. Wash hands thoroughly after application and avoid touching the eyes.
What If I Miss a Dose?
If an application is missed, apply it as soon as remembered unless it’s close to the next scheduled application; do not apply a double amount.
Common Side Effects
Headache, often the most noticeable side effect
Dizziness or light-headedness, especially when standing up quickly
Local burning or irritation at the application site
Serious Side Effects, Seek Help If You Notice:
Fainting or a significant drop in blood pressure
Severe or worsening headache that doesn’t respond to simple pain relief
Signs of an allergic skin reaction
Warnings and Precautions
As outlined in this Rectogesic ointment fissure guide, headache is common because GTN also relaxes blood vessels elsewhere in the body; simple pain relief such as paracetamol can help, but tell your doctor if it’s severe. Use with caution if you have low blood pressure or are prone to fainting, and avoid standing up quickly after application.
Drug and Food Interactions
Do not use with medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil, this combination can cause a dangerous drop in blood pressure.
Storage
Store below 25°C, tube tightly closed, away from heat sources. Keep out of reach of children even after use, as residual ointment on the tube remains active.
Frequently Asked Questions
Why do I get a headache after applying this?
GTN doesn’t stay only in the local area; a small amount is absorbed and relaxes blood vessels throughout the body, which commonly causes headache.
How long until the fissure heals?
Many patients notice reduced pain within days, but full healing of the fissure can take several weeks of consistent use; follow your doctor’s full course.
This article is reviewed by Pharmacist Sesan Kareem, B.Pharm, MPA, MBA and is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always take medicines exactly as prescribed by your doctor. Chat with a HubPharm pharmacist on WhatsApp with any questions before starting, stopping, or changing a medicine.
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